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Effects of corneal thickness on the intraocular penetration of travoprost 0.004%.
| Tipo: | Artículo |
| Código: | PMID: 22562189 |
| Autores: | Martinez-de-la-Casa JM, Rayward O, Saenz-Frances F, Santos-Bueso E, Mendez-Hernandez C, Herrero-Vanrell R, Garcia-Feijoo J, Garcia-Sanchez J. |
| Títuto Revista: | Eye (Lond). |
| Referencia: | |
| Colaboradores: | Instituto de Investigaciones Oftalmológicas Ramón Castroviejo - UCM (RD07-0062-0000)y Grupo de Diseño de Productos Biomateriales Oftálmicos (DEPBO) de la Facultad de Farmacia de la UCM (RD07-0062-2002). |
| Centro: | G09-Madrid |
Abstract
PURPOSE:
To determine whether the intraocular penetration of travoprost 0.004% is affected by central corneal thickness.
METHODS:
Sixty-four patients who were scheduled for cataract surgery without any other ophthalmologic pathology of significance were enrolled in this study. At 120 min before surgery, one drop of travoprost 0.004% was instilled in the eye to be operated on. At the start of surgery, a sample of aqueous humour was extracted to subsequently determine its AL-5848 concentration. These concentrations were compared among three groups of patients established according to central corneal thickness measurements obtained by ultrasound pachymetry.
RESULTS:
Mean AL-5848 concentrations were 3.27±2.03 ng/ml in Group I (CCT<511 microns), 3.27±2.44 ng/ml in Group II (CCT≥511 and ≤574 microns), and 2.73±2.15 ng/ml in Group III (CCT>574 microns), indicating no significant differences among the groups.
CONCLUSIONS:
We were unable to demonstrate the greater or lesser penetration of travoprost depending on corneal thickness, which could explain differences in patient responses to this drug.
