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Hypotensive effect of UDP on intraocular pressure in rabbits.

Tipo: Artículo
Autores: Markovskaya A, Crooke A, Guzmán-Aranguez AI, Peral A, Ziganshin AU, Pintor J.
Títuto Revista: European Journal of Pharmacology
Centro: 08 - UCM - EUÓ
Eur J Pharmacol. 2008 Jan 28;579(1-3):93-7. Epub 2007 Oct 25.

Hypotensive effect of UDP on intraocular pressure in rabbits.


Department of Pharmacology, Kazan State Medical University, Kazan, Russia.


Nucleotides can modify intraocular pressure (IOP). We have tested the ability of uridine-5'-diphosphate, UDP, for modulating IOP in New Zealand white rabbits. Uridine 5' diphosphate, UDP, reduced IOP by 82.9+/-2.6% compared to control. Dose-response analysis demonstrated a concentration dependent pattern which presented a pD(2) value of 7.57+/-1.45, equivalent to an EC(50) of 26.91 nM. Of all the tested P2 receptor antagonists, suramin, pyridoxalphosphate-6-azophenyl-2, 4-disulfonic acid (PPADS) and Reactive Blue 2 (RB-2), only the last two were able to reverse the action triggered by UDP. Altogether, UDP acting probably on P2Y(6) receptors present on the ciliary processes, can reduce intraocular pressure, indicating that this substance may be used for the treatment of ocular hypertension and glaucoma.

PMID: 18031728 [PubMed - indexed for MEDLINE]