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ERG changes in albino and pigmented mice after optic nerve transection.

Tipo: Artículo
Autores: Alarcón-Martínez L, Avilés-Trigueros M, Galindo-Romero C, Valiente-Soriano J, Agudo-Barriuso M, Villa Pde L, Villegas-Pérez MP, Vidal-Sanz M.
Títuto Revista: Vision Research
Colaboradores: Laboratorio de Oftalmología Experimental de la Universidad de Murcia (RD07/0062/0001); Grupo de Fisiología de la Universidad de Alcalá de Henares(RD07/0062/0008).
Centro: 09 - UAH
Vision Res. 2010 Oct 12;50(21):2176-87. Epub 2010 Aug 19.

ERG changes in albino and pigmented mice after optic nerve transection.


Departamento de Oftalmología, Facultad de Medicina, Universidad de Murcia, 30100 Murcia, Spain.


Optic nerve transection (ONT) triggers retinal ganglion cell (RGC) death. By using this paradigm, we have analyzed for the first time in adult albino and pigmented mice, the effects of ONT in the scotopic threshold response (STR) components (negative and positive) of the full-field electroretinogram. Two weeks after ONT, when in pigmented mice approximately 18% of the RGC population survive, the STR-implicit time decreased and the p and nSTR waves diminished approximately to 40% or 55%, in albino or pigmented, respectively, with respect to the values recorded from the non-operated contralateral eyes. These changes were maintained up to 12 weeks post-ONT, demonstrating that the ERG-STR is a useful parameter to monitor RGC functionality in adult mice.

Copyright © 2010 Elsevier Ltd. All rights reserved.

PMID: 20727908 [PubMed - indexed for MEDLINE]