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Time-course of the retinal nerve fibre layer degeneration after complete intra-orbital optic nerve transection or crush: a comparative study.
| Tipo: | Artículo |
| Autores: | Parrilla-Reverter G, Agudo M, Nadal-Nicolás F, Alarcón-Martínez L, Jiménez-López M, Salinas-Navarro M, Sobrado-Calvo P, Bernal-Garro JM, Villegas-Pérez MP, Vidal-Sanz M. |
| Títuto Revista: | Vision Research |
| Referencia: | |
| Centro: | 10 - UM |
Time-course of the retinal nerve fibre layer degeneration after complete intra-orbital optic nerve transection or crush: a comparative study.
Source
Laboratorio de Oftalmología Experimental, Facultad de Medicina, Universidad de Murcia, 30100 Murcia, Spain.
Abstract
We examined qualitatively and quantitatively in adult rat retinas the temporal degeneration of the nerve fibre layer after intra-orbital optic nerve transection (IONT) or crush (IONC). Retinal ganglion cell (RGC) axons were identified by their heavy neurofilament subunit phosphorylated isoform (pNFH) expression. Optic nerve injury induces a progressive axonal degeneration which after IONT proceeds mainly with abnormal pNFH-accumulations in RCG axons and after IONC in RGCs somas and dendrites. Importantly, this aberrant pNFH-expression pattern starts earlier and is more dramatic after IONT than after IONC, highlighting the importance that the type of injury has on the time-course of RGC degeneration.
- PMID: 19715716 [PubMed - indexed for MEDLINE]
