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Combined Pegaptanib sodium (Macugen) and photodynamic therapy in predominantly classic juxtafoveal choroidal neovascularisation in age related macular degeneration.
Tipo: | Artículo |
Autores: | Calvo-González C, Reche-Frutos J, Donate-López J, García-Feijoó J, Leila M, Fernández-Pérez C, Garcia-Sánchez J. |
Títuto Revista: | British Journal of Ophthalmology |
Referencia: | |
Centro: | 06 - UCM - IIORC |
Combined Pegaptanib sodium (Macugen) and photodynamic therapy in predominantly classic juxtafoveal choroidal neovascularisation in age related macular degeneration.
Source
Hospital Universitario Clínico San Carlos, Madrid, Spain. calvo_glez@yahoo.es
Abstract
AIMS:
This prospective, open label, non-comparative, observational case series evaluates 6-month results of Pegaptanib Sodium (Macugen) and Photodynamic Therapy (PDT) in predominantly classic juxtafoveal choroidal neovascularisation (CNV) in age-related macular degeneration (AMD) in seven eyes of seven patients.
RESULTS:
Best corrected visual acuity (BCVA) diminished with a mean of five letters. Initial area of CNV increased significantly from 1.4 mm2 to 2.7 mm2. There was a significant increase in the greatest linear dimension (GLD) from 1280.3 microm to 2065.7 microm at the 24-week follow-up.
CONCLUSION:
Predominantly classic juxtafoveal CNVs are highly aggressive lesions that demonstrate poor response despite combined therapy using PDT and Macugen.
- PMID:
- 18156376
- [PubMed - indexed for MEDLINE]